• Contact
  • EPAD Academy
Top Bar Menu
TwitterFacebookYouTube
Search...
EPADEPAD
EPAD
European Prevention of Alzheimer's Dementia Consortium
  • Home
  • About
    • Welcome to EPAD
    • Project Objectives
      • Project Deliverables
    • Project Structure
    • EPAD Partners
    • Coordination & Management
    • EPAD Q&A
  • For Research Participants
    • Why Participate in EPAD?
      • EPAD & Dementia Research
      • Our Progress
    • Participation in EPAD Trials
    • EPAD Cohort Study
      • Trial Locations
      • EPAD Study Visits
    • EPAD Stories
    • Participation FAQs
  • For Intervention Owners
    • The EPAD Platform
      • Terms of Reference
    • EPAD Benefits
    • Clinical Candidate Selection
      • EPAD Application Process
    • EPAD FAQs
    • Research Resources
  • News & Publications
    • Latest News
    • Newsletters
    • Publications
    • Events
Menu back  

Why is EPAD’s research so important?

EPAD is taking a new approach to clinical trials in Alzheimer’s disease

We now know that subtle changes in the brain may start a decade or more before the symptoms of Alzheimer’s dementia appear. This suggests that a very early form of Alzheimer’s disease process starts well before people start developing typical symptoms like memory loss. If this is the case, then we may be able to identify those people most likely to develop dementia, and possibly prevent or delay the disease from developing into Alzheimer’s dementia.

Currently, doctors can only diagnose Alzheimer’s disease in people who already have dementia or are very close to developing dementia. Available treatments are helpful, but they cannot stop the disease from progressing. EPAD aims to identify changes in the brain which may lead to Alzheimer’s disease before symptoms appear. In theory this is when treatments are most likely to be successful in preventing further spread of the disease in the brain.

EPAD’s approach

We suspect that some treatments will work best in people who share a small number of characteristics. The EPAD approach is to identify these people and invite them to join a clinical trial for a specific medicine. That will allow us to test whether these people respond well to the treatment. If not, we may then be able to identify other people who are more likely to benefit.

We manage this by running EPAD Longitudinal Cohort Study and clinical trial together in the same research programme. This is an unusual approach, but there are great benefits to doing so.  By taking on board many of the lessons learnt over recent years in clinical trials and by studying people at risk of Alzheimer’s before they develop symptoms, EPAD has the opportunity to develop approaches to stop the diseases in its tracks.

Find out how to get involved in EPAD and the progress we are making.

Share this page
FacebookTwitterLinkedInGoogle+
Latest News
  • Interview with Sammy Danso
    2019-01-24
  • Interview with Marija Jovanovic
    2019-01-24
  • Spotlight on Grampian
    2019-01-24
  • Interview with Alejandro Laquidain
    2019-01-17
  • EPAD turns four!
    2019-01-15
Subscribe to our Newsletter

View the EPAD Brochure
thumbnail of EPAD brochure
Speak to the EPAD team
thumbnail of speech bubbles
Twitter
Twitter
EPAD
EPAD
@IMI_EPAD

José Luis Molinuevo (@fpmaragall) mentioned @IMI_EPAD in this spanish report published in the newspaper El País. "We participate in the EPAD project, a consortium between the academic and the private sector to design more efficient Phase II trials" elpais.com/elpais/2019/02… twitter.com/fpmaragall/sta…

reply retweet favorite
10:00 am · 2019-02-14
Twitter
EPAD
EPAD
@IMI_EPAD

.@IMI_EPAD Longitudinal Cohort Study recruitment Update ⤵️ We currently have 21 European sites enrolling and 1450 research participants screened. @IMI_JU @EFPIA @EU_H2020

reply retweet favorite
8:27 am · 2019-02-13
Twitter
EPAD
EPAD
@IMI_EPAD

.@IMI_JU published the first newsletter of the year. Click here to read it: bit.ly/2UlBZE0 twitter.com/IMI_JU/status/…

reply retweet favorite
10:20 am · 2019-02-07
Twitter
EPAD
EPAD
@IMI_EPAD

The @IMI_EPAD center in @NHSGrampian shared with us their tips and tricks to run the EPAD LCS efficiently. Don’t miss the interview: bit.ly/2RKYJ3v twitter.com/IMI_EPAD/statu…

reply retweet favorite
10:17 am · 2019-02-07
Twitter
EPAD
EPAD
@IMI_EPAD

#EPADBerlin19 - Practical scenario about PoC recruitment between a study staff member and a research participant. Remarkable example of an initial conversation to let the participant know he is eligible and ask if he would like to take part in the PoC. pic.twitter.com/cNe2mSphbW

reply retweet favorite
4:38 pm · 2019-02-05
Copyright © 2015-19 EPAD | Created by CMAST and Aridhia
  • Legal Notice
  • Privacy Policy
Bottom Menu

efpia-logo EU imi logo

This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD grant agreement nº 115736

This website uses cookies to improve your experience. Accept Read More