{"id":10258,"date":"2024-03-08T09:09:00","date_gmt":"2024-03-08T08:09:00","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10258"},"modified":"2024-06-04T11:59:47","modified_gmt":"2024-06-04T10:59:47","slug":"facilitating-clinical-use-of-the-amsterdam-instrumental-activities-of-daily-living-questionnaire-normative-data-and-a-diagnostic-cutoff-value","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2024\/03\/08\/facilitating-clinical-use-of-the-amsterdam-instrumental-activities-of-daily-living-questionnaire-normative-data-and-a-diagnostic-cutoff-value\/","title":{"rendered":"Journal of the International Neuropsychological Society"},"content":{"rendered":"\n

“Facilitating clinical use of the Amsterdam Instrumental Activities of Daily Living Questionnaire: Normative data and a diagnostic cutoff value”<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Authors:<\/strong> Merel C. Postema, Mark A. Dubbelman, J\u00fcrgen Claesen, Craig Ritchie, Merike Verrijp, Leonie Visser, Pieter-Jelle Visser, Marissa D. Zwan, Wiesje M. van der Flier and Sietske A.M. Sikkes<\/p>\n\n\n\n

Abstract: <\/strong><\/p>\n\n\n\n

Objective:The Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) is well validated and commonly used to assess difficulties in everyday functioning regarding dementia. To facilitate interpretation and clinical implementation across different European countries, we aim to provide normative data and a diagnostic cutoff for dementia.<\/p>\n\n\n\n

Methods: Cross-sectional data from Dutch Brain Research Registry (N = 1,064; mean (M) age = 62 \u00b1 11 year; 69.5% female), European Medial Information Framework-Alzheimer\u2019s Disease 90 + (N = 63; Mage = 92 \u00b1 2 year; 52.4% female), and European Prevention of Alzheimer\u2019s Dementia Longitudinal Cohort Study (N = 247; Mage = 63 \u00b1 7 year; 72.1% female) were used. The generalized additive models for location, scale, and shape framework were used to obtain normative values (Z-scores). The beta distribution was applied, and combinations of age, sex, and educational attainment were modeled. The optimal cutoff for dementia was calculated using area under receiver operating curves (AUC-ROC) and Youden Index, using data from Amsterdam Dementia Cohort (N = 2,511, Mage = 64 \u00b1 8 year, 44.4% female).<\/p>\n\n\n\n

Results: The best normative model accounted for a cubic-like decrease of IADL performance with age that was more pronounced in low compared to medium\/high educational attainment. The cutoff for dementia was 1.85 standard deviation below the population mean (AUC = 0.97; 95% CI [0.97\u20130.98]).<\/p>\n\n\n\n

Conclusion:We provide regression-based norms for A-IADL-Q and a diagnostic cutoff for dementia, which help improve clinical assessment of IADL performance across European countries.<\/p>\n\n\n\n

DOI:<\/strong> https:\/\/doi.org\/10.1017\/S1355617724000031 <\/a><\/p>\n\n\n\n

Published online:\u00a08 March 2024 in the Journal of the International Neuropsychological Society<\/p>\n","protected":false},"excerpt":{"rendered":"

“Facilitating clinical use of the Amsterdam Instrumental Activities of Daily Living Questionnaire: Normative data and a diagnostic cutoff value” Authors: Merel C. Postema, Mark A. Dubbelman, J\u00fcrgen Claesen, Craig Ritchie, Merike Verrijp, Leonie Visser, Pieter-Jelle Visser, Marissa D. Zwan, Wiesje M. van der Flier and Sietske A.M. Sikkes Abstract: Objective:The Amsterdam Instrumental Activities of Daily […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10258","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10258"}],"version-history":[{"count":7,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10258\/revisions"}],"predecessor-version":[{"id":10322,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10258\/revisions\/10322"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}