{"id":10315,"date":"2023-06-29T11:51:00","date_gmt":"2023-06-29T10:51:00","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10315"},"modified":"2024-06-04T11:56:52","modified_gmt":"2024-06-04T10:56:52","slug":"10315","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2023\/06\/29\/10315\/","title":{"rendered":"Neurobiology of Aging"},"content":{"rendered":"\n<p><strong>&#8220;Spatial cognition is associated with levels of phosphorylated-tau and \u03b2-amyloid in clinically normal older adults&#8221;<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"450\" height=\"200\" src=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png\" alt=\"\" class=\"wp-image-9683\" style=\"width:450px;height:auto\" srcset=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png 450w, https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1-300x133.png 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong> Gillian Coughlan,\u00a0Brennan DeSouza,\u00a0Peter Zhukovsky,\u00a0Michael Hornberger,\u00a0Cheryl Grady,\u00a0Rachel F Buckley;\u00a0European Prevention of Alzheimer\u2019s Disease (EPAD) Consortium<\/p>\n\n\n\n<p><strong>Abstract: <\/strong><\/p>\n\n\n\n<p>Spatial cognition is associated with Alzheimer&#8217;s disease (AD) biomarkers in the symptomatic stages of the disease. We investigated whether cerebrospinal fluid (CSF) biomarkers (phosphorylated-tau [p-tau] and \u03b2-amyloid) are associated with poorer spatial cognition in clinically normal older adults. Participants were 1875 clinically normal adults (age 67.8 [8.5] years) from the European Prevention of Alzheimer&#8217;s Dementia Consortium. Mixed effect models assessed the cross-sectional association between p-tau<sub>181<\/sub>, \u03b2-amyloid<sub>1-42<\/sub> (A\u03b2<sub>1-42<\/sub>) and p-tau<sub>181<\/sub>\/A\u03b2<sub>1-42<\/sub> ratio and spatial cognition measured using semi-automated Supermarket Task and the 4 Mountains Task. Levels of p-tau<sub>181<\/sub>, A\u03b2<sub>1-42,<\/sub> and p-tau<sub>181<\/sub>\/A\u03b2<sub>1-42<\/sub> ratio were significantly associated with spatial cognition scores on both tasks. The p-tau<sub>181<\/sub>\/A\u03b2<sub>1-42<\/sub> ratio showed the largest effect sizes (\u03b2 = -0.04\/0.05, p &lt; 0.001). Lower entorhinal cortical volume was associated with poorer outcomes on both tasks (\u03b2 = 0.06, p &lt; 0.002) and accounted for 18%-22% of the direct association between p-tau<sub>181<\/sub> and spatial cognition scores. In conclusion, degeneration of the entorhinal cortex mediates a significant proportion of the association between p-tau<sub>181<\/sub> and spatial assessments in cognitively normal adults. Future studies should focus on increasing the sensitivity of digital spatial assessments.<\/p>\n\n\n\n<p><strong>DOI:<\/strong> <a href=\"https:\/\/doi.org\/10.1017\/S1355617724000031\"><a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2023.06.016\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.neurobiolaging.2023.06.016<\/a><\/a><\/p>\n\n\n\n<p>Published online:\u00a029 June 2023 in the Journal Neurobiology of Aging<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Spatial cognition is associated with levels of phosphorylated-tau and \u03b2-amyloid in clinically normal older adults&#8221; Authors: Gillian Coughlan,\u00a0Brennan DeSouza,\u00a0Peter Zhukovsky,\u00a0Michael Hornberger,\u00a0Cheryl Grady,\u00a0Rachel F Buckley;\u00a0European Prevention of Alzheimer\u2019s Disease (EPAD) Consortium Abstract: Spatial cognition is associated with Alzheimer&#8217;s disease (AD) biomarkers in the symptomatic stages of the disease. We investigated whether cerebrospinal fluid (CSF) biomarkers (phosphorylated-tau [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10315","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10315"}],"version-history":[{"count":2,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10315\/revisions"}],"predecessor-version":[{"id":10320,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10315\/revisions\/10320"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}