{"id":10431,"date":"2024-06-11T10:37:19","date_gmt":"2024-06-11T09:37:19","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10431"},"modified":"2024-07-22T10:43:17","modified_gmt":"2024-07-22T09:43:17","slug":"journal-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2024\/06\/11\/journal-of-alzheimers-disease\/","title":{"rendered":"Journal of Alzheimer&#8217;s Disease"},"content":{"rendered":"\n<p><strong>&#8220;Semantic Harmonization of Alzheimer\u2019s Disease Datasets Using AD-Mapper&#8221;<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"900\" height=\"400\" src=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2019\/05\/EPAD-logo-1.jpg\" alt=\"\" class=\"wp-image-3200\" srcset=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2019\/05\/EPAD-logo-1.jpg 900w, https:\/\/ep-ad.org\/wp-content\/uploads\/2019\/05\/EPAD-logo-1-300x133.jpg 300w, https:\/\/ep-ad.org\/wp-content\/uploads\/2019\/05\/EPAD-logo-1-768x341.jpg 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong> Philipp Wegner, Helena Balabin,Mehmet Can Ay, Sarah Bauermeister, Lewis Killin, John Gallacher, Martin Hofmann-Apitius, Yasamin Salimi, for the Alzheimer\u2019s Disease Neuroimaging Initiative, the Japanese Alzheimer\u2019s Disease Neuroimaging Initiative, the Aging Brain: Vasculature, Ischemia, and Behavior Study, the Alzheimer\u2019s Disease Repository Without Borders Investigators, and the European Prevention of Alzheimer\u2019s Disease (EPAD) Consortium<\/p>\n\n\n\n<p><strong>Abstract:<\/strong> <\/p>\n\n\n\n<p>Background:Despite numerous past endeavors for the semantic harmonization of Alzheimer\u2019s disease (AD) cohort studies, an automatic tool has yet to be developed. <\/p>\n\n\n\n<p>Objective: As cohort studies form the basis of data-driven analysis, harmonizing them is crucial for cross-cohort analysis. We aimed to accelerate this task by constructing an automatic harmonization tool.<\/p>\n\n\n\n<p>Methods: We created a common data model (CDM) through cross-mapping data from 20 cohorts, three CDMs, and ontology terms, which was then used to fine-tune a BioBERT model. Finally, we evaluated the model using three previously unseen cohorts and compared its performance to a string-matching baseline model.<\/p>\n\n\n\n<p>Results: Here, we present our AD-Mapper interface for automatic harmonization of AD cohort studies, which outperformed a string-matching baseline on previously unseen cohort studies. We showcase our CDM comprising 1218 unique variables.<\/p>\n\n\n\n<p>Conclusion: AD-Mapper leverages semantic similarities in naming conventions across cohorts to improve mapping performance.<\/p>\n\n\n\n<p><strong>DOI:<\/strong> <a href=\"https:\/\/doi.org\/10.3233%2FJAD-240116\" target=\"_blank\" rel=\"noreferrer noopener\">10.3233\/JAD-240116<\/a><\/p>\n\n\n\n<p>Published online on 11 June 2024 in the Journal of Alzheimer&#8217;s Disease<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Semantic Harmonization of Alzheimer\u2019s Disease Datasets Using AD-Mapper&#8221; Authors: Philipp Wegner, Helena Balabin,Mehmet Can Ay, Sarah Bauermeister, Lewis Killin, John Gallacher, Martin Hofmann-Apitius, Yasamin Salimi, for the Alzheimer\u2019s Disease Neuroimaging Initiative, the Japanese Alzheimer\u2019s Disease Neuroimaging Initiative, the Aging Brain: Vasculature, Ischemia, and Behavior Study, the Alzheimer\u2019s Disease Repository Without Borders Investigators, and the European [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10431","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10431"}],"version-history":[{"count":3,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10431\/revisions"}],"predecessor-version":[{"id":10434,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10431\/revisions\/10434"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}