{"id":10463,"date":"2024-11-25T11:14:13","date_gmt":"2024-11-25T10:14:13","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10463"},"modified":"2025-01-27T11:18:22","modified_gmt":"2025-01-27T10:18:22","slug":"sagejournals","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2024\/11\/25\/sagejournals\/","title":{"rendered":"SageJournals"},"content":{"rendered":"\n<p>&#8220;Blood-brain barrier permeable \u03b2-blockers association with Alzheimer&#8217;s disease cerebrospinal fluid biomarkers levels in non-demented individuals&#8221;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"450\" height=\"200\" src=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png\" alt=\"\" class=\"wp-image-9683\" srcset=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png 450w, https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1-300x133.png 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong> \u00a0<br>Mariateresa Buongiorno, Gonzalo S\u00e1nchez-Benavides, Clara Marzal-Esp\u00ed, Darly Milena Giraldo, Jerzy Krupinski, Natalia Cullell, Oriol Grau-Rivera, Marc Su\u00e1rez-Calvet, Juan Domingo Gispert, Alex de la Sierra, and for the Alzheimer&#8217;s Disease Neuroimaging Initiative, and the European Prevention of Alzheimer&#8217;s Disease (EPAD) Consortium<\/p>\n\n\n\n<p><strong>Abstract:<\/strong><\/p>\n\n\n\n<p>\u03b2-blockers that easily cross the blood-brain barrier (BBB) seem to diminish the risk of Alzheimer&#8217;s disease (AD), hypothetically facilitating waste clearance. However, their effect on AD pathophysiological markers is unknown. We compared cerebrospinal fluid (CSF) AD biomarker levels among non-demented individuals taking low, intermediate, or high BBB permeable \u03b2-blockers in two samples (ADNI: <em>n<\/em>\u2009=\u2009216; EPAD: <em>n<\/em>\u2009=\u200979). We found that CSF amyloid-\u03b2 levels were higher in individuals taking highly permeable \u03b2-blockers in the ADNI sample. This result was not replicated in EPAD, in which diminished levels of pTau181 and tTau were observed. These data suggest that \u03b2-blockers may impact AD pathophysiology.<\/p>\n\n\n\n<p><strong>DOI:<\/strong> <a href=\"https:\/\/doi.org\/10.1177\/13872877241293812\">https:\/\/doi.org\/10.1177\/13872877241293812<\/a><\/p>\n\n\n\n<p>Published online: 25 November 2024 in SAGEJournals<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Blood-brain barrier permeable \u03b2-blockers association with Alzheimer&#8217;s disease cerebrospinal fluid biomarkers levels in non-demented individuals&#8221; Authors: \u00a0Mariateresa Buongiorno, Gonzalo S\u00e1nchez-Benavides, Clara Marzal-Esp\u00ed, Darly Milena Giraldo, Jerzy Krupinski, Natalia Cullell, Oriol Grau-Rivera, Marc Su\u00e1rez-Calvet, Juan Domingo Gispert, Alex de la Sierra, and for the Alzheimer&#8217;s Disease Neuroimaging Initiative, and the European Prevention of Alzheimer&#8217;s Disease (EPAD) [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10463","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10463"}],"version-history":[{"count":1,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10463\/revisions"}],"predecessor-version":[{"id":10465,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10463\/revisions\/10465"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}