{"id":10467,"date":"2025-02-03T08:26:06","date_gmt":"2025-02-03T07:26:06","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10467"},"modified":"2025-02-04T08:31:31","modified_gmt":"2025-02-04T07:31:31","slug":"alzheimers-dementia-3","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2025\/02\/03\/alzheimers-dementia-3\/","title":{"rendered":"Alzheimer’s & Dementia"},"content":{"rendered":"\n

“Soluble A\u03b2 pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer’s continuum<\/em>: Evidence across two independent cohorts”<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Authors:<\/strong> Raffaele Cacciaglia,\u00a0Carles Falc\u00f3n,\u00a0Gonzalo S\u00e1nchez Benavides,\u00a0Anna Brugulat-Serrat,\u00a0Marta Mil\u00e0 Alom\u00e0,\u00a0Marc Su\u00e1rez Calvet,\u00a0Jos\u00e9 Luis Molinuevo,\u00a0Karine Fauria,\u00a0Carolina Minguill\u00f3n,\u00a0Gwendlyn Kollmorgen,\u00a0Clara Quijano-Rubio,\u00a0Kaj Blennow,\u00a0Henrik Zetterberg,\u00a0Luigi Lorenzini,\u00a0Alle Meije Wink,\u00a0Silvia Ingala,\u00a0Frederik Barkhof,\u00a0Craig W. Ritchie,\u00a0Juan Domingo Gispert,\u00a0for the ALFA study<\/p>\n\n\n\n

Abstract:<\/strong><\/p>\n\n\n\n

Introduction: Identifying the link between early Alzheimer’s disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. We assessed longitudinal brain atrophy and cognitive decline as a function of cerebrospinal fluid (CSF) AD biomarkers in two independent cohorts of cognitively unimpaired (CU) individuals.<\/p>\n\n\n\n

Methods: We used longitudinal voxel-based morphometry (VBM) in combination with hippocampal subfield segmentation. Changes in neuroimaging and cognitive variables were inspected using general linear models (GLMs) adjusting by age, sex, apolipoprotein E (APOE)<\/em> status, follow-up time, and years of education.<\/p>\n\n\n\n

Results: In both cohorts, baseline CSF amyloid beta (A\u03b2) biomarkers significantly predicted medial temporal lobe (MTL) atrophy rates and episodic memory (EM) decline independently of CSF phosphorylated tau (p-tau).<\/p>\n\n\n\n

Discussion: Our data suggest that soluble A\u03b2 dyshomeostasis triggers MTL longitudinal atrophy and EM decline independently of CSF p-tau. Our data underscore the need for secondary preventive strategies at the earliest stages of the AD pathological cascade.<\/p>\n\n\n\n

Highlights: Our results underscore the importance of undertaking Alzheimer’s preclinical trials. We assessed brain atrophy and cognitive decline in asymptomatic individuals. A\u03b2 biomarkers predicted MTL atrophy independently of p-tau.<\/p>\n\n\n\n

DOI: <\/strong>doi.org\/10.1002\/alz.14415<\/a><\/p>\n\n\n\n

Published online:\u00a03 February 2025 in the journal Alzheimer’s & Dementia: the journal of the Alzheimer’s Association<\/p>\n","protected":false},"excerpt":{"rendered":"

“Soluble A\u03b2 pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer’s continuum: Evidence across two independent cohorts” Authors: Raffaele Cacciaglia,\u00a0Carles Falc\u00f3n,\u00a0Gonzalo S\u00e1nchez Benavides,\u00a0Anna Brugulat-Serrat,\u00a0Marta Mil\u00e0 Alom\u00e0,\u00a0Marc Su\u00e1rez Calvet,\u00a0Jos\u00e9 Luis Molinuevo,\u00a0Karine Fauria,\u00a0Carolina Minguill\u00f3n,\u00a0Gwendlyn Kollmorgen,\u00a0Clara Quijano-Rubio,\u00a0Kaj Blennow,\u00a0Henrik Zetterberg,\u00a0Luigi Lorenzini,\u00a0Alle Meije Wink,\u00a0Silvia Ingala,\u00a0Frederik Barkhof,\u00a0Craig W. Ritchie,\u00a0Juan Domingo Gispert,\u00a0for the ALFA study Abstract: Introduction: Identifying […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10467","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10467"}],"version-history":[{"count":2,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10467\/revisions"}],"predecessor-version":[{"id":10480,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10467\/revisions\/10480"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}