{"id":10520,"date":"2025-10-14T11:26:47","date_gmt":"2025-10-14T10:26:47","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10520"},"modified":"2025-10-21T11:32:49","modified_gmt":"2025-10-21T10:32:49","slug":"alzheimers-dementia-4","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2025\/10\/14\/alzheimers-dementia-4\/","title":{"rendered":"Alzheimer&#8217;s &amp; Dementia"},"content":{"rendered":"\n<p>&#8220;Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning&#8221;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"450\" height=\"200\" src=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png\" alt=\"\" class=\"wp-image-9683\" srcset=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png 450w, https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1-300x133.png 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong> Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Merc\u00e8 Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, Gill Farrar, Wiesje van der Flier, Giovanni B. Frisoni, Rossella Gismondi, Juan Domingo Gispert, Bernard J. Hanseeuw, Frank Jessen, Marta Marqui\u00e9, Anja Mett, Craig Ritchie, Gemma Salvad\u00f3, Michael Sch\u00f6ll, Mahnaz Shekari, Andrew W. Stephens, Betty M. Tijms, David V\u00e1llez Garc\u00eda, Rik Vandenberghe, Pieter Jelle Visser, Luca Roccatagliata, Neil P. Oxtoby, Matteo Pardini, Frederik Barkhof<\/p>\n\n\n\n<p><strong>Abstract:<\/strong><\/p>\n\n\n\n<p>Introduction: The emergence, stability, and contributing factors of Alzheimer&#8217;s disease (AD) gray matter subtypes remain unclear.<\/p>\n\n\n\n<p>Methods: We analyzed data from 1323 individuals without a diagnosis of dementia (CDR\u00a0&lt;\u00a01) with T1w-MRI and amyloid-PET, including 622 with longitudinal data (3.66\u00a0\u00b1\u00a01.78 years). Cortical thickness subtypes were identified using a non-negative matrix factorization (NMF) clustering algorithm. We examined clinical and demographic differences, subtype stability, and longitudinal thinning patterns using brain network models and imaging-transcriptomic analysis. Replication was performed with an alternative clustering approach and a validation cohort.<\/p>\n\n\n\n<p>Results: Two stable subtypes emerged: limbic-predominant and hippocampal-sparing. Limbic-predominant participants were older, had higher amyloid burden, and faster memory decline, while hippocampal-sparing individuals showed greater attention and executive function decline. Distinct thinning patterns were linked to specific network properties and gene expression profiles.<\/p>\n\n\n\n<p>Discussion: These MRI-based subtypes reflect underlying pathophysiological mechanisms and may aid in prognostication and clinical trial stratification.<\/p>\n\n\n\n<p><strong>DOI<\/strong>: <a href=\"https:\/\/doi.org\/10.1002\/alz.70762\">https:\/\/doi.org\/10.1002\/alz.70762<\/a><\/p>\n\n\n\n<p>Published online:\u00a014 October 2025 in the journal Alzheimer&#8217;s &amp; Dementia<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning&#8221; Authors: Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Merc\u00e8 Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10520","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10520"}],"version-history":[{"count":1,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10520\/revisions"}],"predecessor-version":[{"id":10521,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10520\/revisions\/10521"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}