{"id":10540,"date":"2025-10-30T09:28:12","date_gmt":"2025-10-30T08:28:12","guid":{"rendered":"https:\/\/ep-ad.org\/?p=10540"},"modified":"2026-01-26T09:33:09","modified_gmt":"2026-01-26T08:33:09","slug":"alzheimers-dementia-5","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2025\/10\/30\/alzheimers-dementia-5\/","title":{"rendered":"Alzheimer’s & Dementia"},"content":{"rendered":"\n

“The association of diabetes with Alzheimer’s disease biomarkers and vascular burden across European aging and memory clinic cohorts”<\/p>\n\n\n\n

\"This<\/figure>\n\n\n\n

Authors:<\/strong> Veerle van Gils, Willemijn J. Jansen, Wiesje M. van der Flier, Pablo Martinez-Lage, Jakub Hort, Inez H. G. B. Ramakers, Olivier Rouaud, Markku Laakso, Sebastiaan Engelborghs, Julius Popp, Alberto Lle\u00f3, Anders Wallin, Magda Tsolaki, Charlotte E. Teunissen, Rik Vandenberghe, Yvonne Freund-Levi, Lutz Fr\u00f6lich, Henrik Zetterberg, Johannes Streffer, Simon Lovestone, Justine Moonen, Argonde van Harten, Katerina Veverov\u00e1, Nienke Legdeur, Anouk den Braber, Daniel Damian, Anette Hall, Janita Bralten, Giuseppe Fanelli, Barbara Franke, Geert Poelmans, Monica Bull\u00f3, Susana Jimenez-Murcia, Fernando Fernandez-Aranda, Jordi Salas-Salvad\u00f3, S\u00f8ren Dalsgaard, Pieter Jelle Visser, Stephanie J. B. Vos<\/p>\n\n\n\n

Abstract:<\/strong><\/p>\n\n\n\n

Introduction: It remains unclear whether diabetes mellitus (DM) is associated with Alzheimer’s disease (AD) pathology and associated vascular burden.<\/p>\n\n\n\n

Methods: We included cognitively normal (CN), mild cognitive impairment (MCI), and dementia individuals. We assessed associations between DM and AD biomarkers (amyloid beta [A\u03b2], phosphorylated tau\u2010181 [p\u2010tau181], total tau [t\u2010tau], and medial temporal atrophy [MTA]) and vascular burden (white matter hyperintensities, microbleeds) by logistic regression. Secondary analyses assessed associations between DM and profiles of A\u03b2 combined with p\u2010tau181\/t\u2010tau\/MTA\/white matter hyperintensity\/microbleeds.<\/p>\n\n\n\n

Results: We included 5550 participants (65.8+\u20108.7 years, 8.7% DM). DM was associated with lower odds of abnormal AD biomarkers: A\u03b2 in MCI (odds ratio [OR]\u00a0=\u00a00.70, 95% confidence interval [CI]: 0.51\u20130.95, p\u00a0<\/em>=\u00a00.02) and dementia (OR\u00a0=\u00a00.44, 0.26\u20130.78, p<\/em>\u00a0=\u00a00.003), and p\u2010tau181 in dementia (OR\u00a0=\u00a00.64, 0.41\u20131.00, p<\/em>\u00a0=\u00a00.045). Secondary analyses indicated associations of DM with abnormal t\u2010tau (OR\u00a0=\u00a01.57, 1.00\u20132.46, p<\/em>\u00a0=\u00a00.048) and MTA (OR\u00a0=\u00a01.96, 1.05\u20133.68, p<\/em>\u00a0=\u00a00.04) only in CN individuals with normal A\u03b2.<\/p>\n\n\n\n

Discussion: In cognitively impaired individuals, DM was associated with lower odds of A\u03b2 pathology, whereas DM was associated with neurodegeneration markers in CN individuals without A\u03b2 pathology.<\/p>\n\n\n\n

DOI<\/strong>: <\/a><\/a><\/a>https:\/\/doi.org\/10.1002\/alz.70804<\/a><\/p>\n\n\n\n

Published online:\u00a030 October 2025 in the journal of Alzheimer’s & Dementia<\/p>\n","protected":false},"excerpt":{"rendered":"

“The association of diabetes with Alzheimer’s disease biomarkers and vascular burden across European aging and memory clinic cohorts” Authors: Veerle van Gils, Willemijn J. Jansen, Wiesje M. van der Flier, Pablo Martinez-Lage, Jakub Hort, Inez H. G. B. Ramakers, Olivier Rouaud, Markku Laakso, Sebastiaan Engelborghs, Julius Popp, Alberto Lle\u00f3, Anders Wallin, Magda Tsolaki, Charlotte E. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10540","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=10540"}],"version-history":[{"count":3,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10540\/revisions"}],"predecessor-version":[{"id":10548,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/10540\/revisions\/10548"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=10540"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=10540"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=10540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}