{"id":3041,"date":"2019-04-01T11:36:22","date_gmt":"2019-04-01T09:36:22","guid":{"rendered":"https:\/\/alzheimer.noemi.lu\/?p=3041"},"modified":"2019-04-01T11:36:22","modified_gmt":"2019-04-01T09:36:22","slug":"fundacio-ace-joins-epad-for-dementia-prevention","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2019\/04\/01\/fundacio-ace-joins-epad-for-dementia-prevention\/","title":{"rendered":"Fundaci\u00f3 ACE joins EPAD for dementia prevention"},"content":{"rendered":"\n<div class=\"wp-block-media-text alignwide\"><figure class=\"wp-block-media-text__media\"><img alt=\"\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-large-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<p><strong><a href=\"https:\/\/www.fundacioace.com\/en\">Fundaci\u00f3 ACE<\/a> \u2013 Barcelona Alzheimer Treatment &amp; Research Center<\/strong>, an entity devoted to the diagnosis, treatment, research and awareness on Alzheimer&#8217;s disease, has been incorporated into <a href=\"https:\/\/alzheimer.noemi.lu\/\"><strong>EPAD<\/strong><\/a><strong> (European Prevention of Alzheimer&#8217;s Dementia Consortium)<\/strong>, a European consortium aiming to <strong>work for the prevention of Alzheimer&#8217;s dementia through an interdisciplinary research program<\/strong>.<\/p>\n\n\n\n<p>Facing the evidence that Alzheimer&#8217;s disease\ncauses brain alterations prior to the onset of symptoms, this project focuses on\nthe early phases of the disease to <strong>develop actions that help to prevent and\ntreat this type of dementia<\/strong>. In recent years, research has increasingly\nfocused on this presymptomatic phase in order to offer new preventive\ntreatments and to intervene more effectively.<\/p>\n\n\n\n<p>EPAD is the largest public-private consortium in the field of Alzheimer&#8217;s research thanks to the participation of multiple collaborating organisations and more than 1,500 registered participants to date. Fundaci\u00f3 ACE becomes a new member of the group and one of the three representatives of Spain, together with the Pasqual Maragall Foundation research center, the Barcelona\u03b2eta Brain Research Center, and the Alzheimer&#8217;s CITA Foundation.<\/p>\n\n\n\n<p>Dr. <strong>Merc\u00e8 Boada<\/strong>, medical director of Fundaci\u00f3 ACE, attended, last February in Berlin a follow-up meeting of the project along with other experts from the organisation such as Dr. <strong>Agust\u00edn Ruiz<\/strong>, research director, Dr. Carla Abdelnour, attached to the Clinical Trials Unit, and <strong>Mar Buendia<\/strong>, clinical trials coordinator.<\/p>\n\n\n\n<p>Dr. Boada expressed satisfaction with the recent incorporation of the Foundation to the project.<em> &#8220;In recent years, at Fundaci\u00f3 ACE we focused on the early detection of Alzheimer&#8217;s and we devoted many efforts in this direction. It is not an easy task; It is a challenge in which we keep on putting efforts day by day. This is why, we are convinced that it will be very positive to be part of a project that pools the knowledge of so many entities and experts and unites efforts in the prevention and treatment of dementia&#8221;<\/em> she comments.<\/p>\n\n\n\n<pre class=\"wp-block-preformatted\"><strong><em>&nbsp;<\/em><\/strong>&nbsp;<\/pre>\n\n\n\n<p class=\"has-medium-font-size\"><strong>The challenges of EPAD<\/strong><\/p>\n\n\n\n<p>In order to carry out its work, EPAD faces several challenges, such as the difficulty of identifying people who may end up developing Alzheimer&#8217;s, the lack of understanding of the earliest stages of the illness or the lack of flexibility in the clinical trials development.<\/p>\n\n\n\n<p>To address these difficulties, the Consortium developed\nthree basic strategies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The Register: <\/strong>EPAD will create the first single, pan-European register of over half a million people across the risk spectrum for dementia.<\/li><li><strong>The Cohort: <\/strong>From this register, research participants are invited to join an EPAD cohort of at-risk subjects. At present, more than 1,500 participants from centres throughout Europe with standardized tests are being part of this cohort and are followed for several years.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The Trial: <\/strong>EPAD will select\nsuitable participants to take part in adaptive trials of drugs designed to\nprevent Alzheimer\u2019s dementia. In fact, EPAD is a\npioneering platform in the implementation of this method. In traditional\nclinical trials, half of the participants receive the drug under investigation,\nand half receive a placebo. In adaptive clinical trials, several candidate\ndrugs are simultaneously compared to each other and to a placebo, meaning that\na greater proportion of patients benefit from a potentially active treatment.<\/li><\/ul>\n\n\n\n<p>As a result, <strong>a greater proportion of people benefit from a potentially active treatment to reduce the risk of developing dementia in the future<\/strong>. Furthermore, researchers can adapt the trial design in response to emerging results, new candidate drugs can be added, and those that prove ineffective can be dropped. With better data and better decision making, <strong>the adaptive tests can increase the likelihood of success and decrease the duration of the development<\/strong>. EPAD started in 2015 and is made up of research centers, universities, pharmaceutical laboratories and associations of patients from all over Europe. The consortium is funded with the subsidy number 115736 of the Innovative Medicines Initiative, which is a joint initiative of the European Commission research and innovation program Horizon 2020 and  the European Federation of Pharmaceutical Industries and Associations (EFPIA). <\/p>\n\n\n\n<p class=\"has-medium-font-size\"><br><strong>About Fundaci\u00f3 ACE, a pioneering model in the world of Alzheimer&#8217;s<\/strong><\/p>\n\n\n\n<p><em>Fundaci\u00f3 ACE &#8211; Barcelona Alzheimer\nTreatment &amp; Research Center, an innovative and reference entity in Spain,\nwas created in 1995 with the aim of addressing the growing demand in the\ndiagnosis and treatment of people with cognitive impairment and dementia,\nespecially Alzheimer&#8217;s, offering personalized attention and comprehensive\naccompaniment to patients and their families. Fundaci\u00f3 ACE is considered one of\nthe international benchmarks in research, especially clinical, social,\nneuropsychological and basic research.<\/em><\/p>\n\n\n\n<p><em>Every year more than 7,000 people go through their Diagnostic Unit. 4,000 of those have dementia (3,000 of them, Alzheimer\u2019s type). Among other research activities, Fundaci\u00f3 ACE participates in numerous clinical trials involving worldwide participation in all the phases of the disease. Its team is currently leading two research projects funded by the European Union on Alzheimer&#8217;s Genetics (ADAPTED) and on models of patient engagement (MOPEAD).<\/em><\/p>\n\n\n\n<p class=\"has-medium-font-size\">For further information<strong>: <\/strong><\/p>\n\n\n\n<p>M. Dolors Cuenca<br>677 14 57 65<br><a href=\"mailto:mdcuenca@undatia.es\">mdcuenca@undatia.es<\/a><\/p>\n\n\n\n<p>Isabel Rodr\u00edguez<br>93 444 73 18<br>irodriguez@fundacioace.org <\/p>\n\n\n\n<p>Check out the Spanish press release <a href=\"http:\/\/geriatricarea.com\/fundacio-ace-se-une-al-proyecto-europeo-epad-para-la-prevencion-y-deteccion-precoz-del-alzheimer\/\">here.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fundaci\u00f3 ACE \u2013 Barcelona Alzheimer Treatment &amp; Research Center, an entity devoted to the diagnosis, treatment, research and awareness on Alzheimer&#8217;s disease, has been incorporated into EPAD (European Prevention of Alzheimer&#8217;s Dementia Consortium), a European consortium aiming to work for the prevention of Alzheimer&#8217;s dementia through an interdisciplinary research program. Facing the evidence that Alzheimer&#8217;s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3042,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3041","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/3041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=3041"}],"version-history":[{"count":0,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/3041\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media\/3042"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=3041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=3041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=3041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}