{"id":9819,"date":"2022-08-27T07:48:00","date_gmt":"2022-08-27T06:48:00","guid":{"rendered":"https:\/\/alzheimer.noemiconcept.com\/?p=9819"},"modified":"2024-06-04T11:31:06","modified_gmt":"2024-06-04T10:31:06","slug":"interactions-between-apolipoprotein-e-sex-and-amyloid-betaon-cerebrospinal-fluid-p-tau-levels-in-the-european-preventionof-alzheimers-dementia-longitudinal-cohort-study-epad-lcs","status":"publish","type":"post","link":"https:\/\/ep-ad.org\/index.php\/2022\/08\/27\/interactions-between-apolipoprotein-e-sex-and-amyloid-betaon-cerebrospinal-fluid-p-tau-levels-in-the-european-preventionof-alzheimers-dementia-longitudinal-cohort-study-epad-lcs\/","title":{"rendered":"EBioMedicine"},"content":{"rendered":"\n<p><strong>&#8220;Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer&#8217;s dementia longitudinal cohort study (EPAD LCS)&#8221;<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"450\" height=\"200\" src=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png\" alt=\"\" class=\"wp-image-9683\" srcset=\"https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1.png 450w, https:\/\/ep-ad.org\/wp-content\/uploads\/2015\/05\/Logo-EPAD-e1442819956731-1-300x133.png 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong> Tyler S. Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchieand Graciela Muniz-Terrera<\/p>\n\n\n\n<p><strong>Abstract: <\/strong><\/p>\n\n\n\n<p>Background: Alzheimer&#8217;s Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE)\u03b54 allele is the strongest genetic risk factor for late-onset AD and is associated with aberrant cerebrospinal fluid levels (CSF) of total tau (t-tau), phosphorylated tau (p-tau), and amyloid-\u03b2 (A\u03b2). There is some evidence that sex may mediate the relationship between APOE status and CSF tau, however, evidence is mixed.<\/p>\n\n\n\n<p>Methods: We aimed to examine the interaction between sex, APOE \u03b54 status, CSF A\u03b2 on t-tau and p-tau in 1599 mid-to-late life individuals without a diagnosis of dementia in the European Prevention of Alzheimer&#8217;s Dementia (EPAD) longitudinal cohort study.<\/p>\n\n\n\n<p>Findings: We found a significant interaction between APOE status, sex, and CSF A\u03b2 on CSF p-tau levels (\u03b2 = 0\u00b718, p = 0\u00b704). Specifically, there was a stronger association between APOE status and CSF A\u03b2<sub>42<\/sub> on CSF p-tau in males compared to females. Further, in females with high A\u03b2 levels (reflecting less cortical deposition), \u03b54 carriers had significantly elevated p-tau levels relative to non-carriers (W = 39663, p = 0\u00b701). However, there were no significant differences in p-tau between male \u03b54 carriers and non-carriers with high A\u03b2 (W = 23523, p = 0\u00b764).<\/p>\n\n\n\n<p>Interpretation: An interaction between sex and cerebrospinal fluid A\u03b2 may mediate the relationship between APOE status and CSF p-tau. These data suggest tau accumulation may be independent of A\u03b2 in females, but not males.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>DOI:<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104241\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.ebiom.2022.104241<\/a><\/p>\n\n\n\n<p>Published online:\u00a027 August 2022 in the journal EBioMedicine<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer&#8217;s dementia longitudinal cohort study (EPAD LCS)&#8221; Authors: Tyler S. Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchieand Graciela Muniz-Terrera Abstract: Background: Alzheimer&#8217;s Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE)\u03b54 allele is [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-9819","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/9819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/comments?post=9819"}],"version-history":[{"count":4,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/9819\/revisions"}],"predecessor-version":[{"id":10307,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/posts\/9819\/revisions\/10307"}],"wp:attachment":[{"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/media?parent=9819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/categories?post=9819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ep-ad.org\/index.php\/wp-json\/wp\/v2\/tags?post=9819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}