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The European Prevention of
Alzheimer’s Dementia
Consortium

There’s an urgent need to break new ground in the fight against Alzheimer’s dementia. The number of people affected worldwide is expected to reach over 100 million by 2050. Therefore, right now is a crucial time for the development of effective treatments.

We recruited over 2000 research participants into a four-year EPAD Longitudinal Cohort Study (LCS) exploring new ways to better understand the early stages of Alzheimer’s disease and prevent dementia before symptom onset.

The data, bio samples, and neuroimaging generated from our study are available for researchers studying the brain and neurodegenerative diseases around the world.

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EPAD at AD/PD 2025: Advances in Science and Therapy

International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders | April 1-5, 2025 | Vienna, Austria|

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Explore our Open Source Data and Samples

By making our data and samples publicly accessible, our goal is to facilitate global collaboration amongst brain scientists and researchers working in the field to improve the understanding of the early stages of Alzheimer’s disease and accelerate treatment options.

EPAD dataset

Thanks to an innovative screening process, the EPAD LCS dataset is unique, as 37% of the sample was amyloid positive at enrollment. Additional data includes information on biomarkers, cognition, sociodemographic, and vital signs.

Neuroimaging

The EPAD imaging dataset includes core (3D T1w, 3D FLAIR) and advanced (ASL, diffusion MRI, and resting-state fMRI) MRI sequences. Core Sequences were acquired for all participants while advanced sequences have been obtained from a subset of scanning sites, for around 70% of
participants.

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Bio samples

The EPAD biobank includes blood, CSF, saliva, and urine collected over the course of our longitudinal study. Our bespoke database and information management system provides traceability and sample
validation.

Discover the latest EPAD news and publications.

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News

  • EPAD at AD/PD2025

    The AD/PD™ Alzheimer’s disease and Parkinson’s disease Conference will take place between 1-5 April in Vienna, Austria. The conference will present all the latest breakthroughs in treatment, translational R&D, early…

    Read more: EPAD at AD/PD2025

Videos

Publication

  • Human Brain Mapping

    “Grey-Matter Structure Markers of Alzheimer’s Disease, Alzheimer’s Conversion, Functioning and Cognition: A Meta-Analysis Across 11 Cohorts” Authors: Baptiste Couvy-Duchesne, Vincent Frouin, Vincent Bouteloup, Nikitas Koussis, Julia Sidorenko, Jiyang Jiang, Alle Meije Wink, Luigi Lorenzini, Frederik Barkhof, Julian N. Trollor, Jean-François Mangin, Perminder S. Sachdev, Henry Brodaty, Michelle K. Lupton, Michael Breakspear, Olivier Colliot, Peter M.…

    Read more: Human Brain Mapping

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