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EPAD
European Prevention of Alzheimer's Dementia Consortium
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Welcome to EPAD

EPAD - the European Prevention of Alzheimer's Dementia Consortium - was an interdisciplinary research programme spanning public and private sector organisations across Europe, with 39 partners, ending October 2020.


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  • EPAD is part of a global initiative that will make a fundamental difference to the understanding and management of Alzheimer’s disease in people with very early or no symptoms at all. This could be a game-changer. It is only possible because of the absolute commitment of academics, industry, policy makers and the public to work hand in hand to defeat this global threat.

    Prof Craig Ritchie
    EPAD Co-coordinator and Professor of the Psychiatry of Ageing at the University of Edinburgh
  • This project has numerous advantages over current approaches. These include the excellent pre-trial characterisation of research participants to inform selection and reduce screen failure, the establishment of the highest possible quality study sites across Europe, the rapid decision making on the likely success of a drug (or combination of drugs) in subsequent confirmatory trials as well as access to a shared placebo group.

    Serge Van der Geyten
    EPAD Coordinator and Director for Neuroscience External Affairs at Janssen Pharmaceutica NV
  • One of our biggest learnings, after several efforts that didn’t yield the result that we hope for, was that we probably wanted to intervene much earlier. We see there is an opportunity to affect the disease early before significant damage is done and give these disease modifying drugs a chance to show what they can do. Number one is identifying accurately that population in terms of who would benefit most from pharmacological intervention. And the second main challenge is then how does one make decisions on outcomes, as to whether drugs are effective in a population that may well be entirely asymptomatic.

    Luc Truyen
    Vice-President Neuroscience External Affairs at Janssen R&D
  • Preventing the development of dementia in biomarker-positive people would be a fantastic step forward in our fight against Alzheimer’s disease. The EPAD and its novel trial concept will hopefully help speed up the drug discovery progress and bring us closer to this ambitious aim.

    Jean Georges
    Executive Director of Alzheimer Europe

EPAD’s Objectives

Despite significant global investment, there have been no new drugs for Alzheimer’s disease for 20 years. There is an urgent need for new treatments.

Learn more

EPAD Partners

EPAD was a unique collaborative research effort. Our 39 partners across Europe were committed to transforming our understanding of Alzheimer’s disease.

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Latest News
  • The final EPAD dataset is now available to the entire research community
    2020-11-30
  • ALZFORUM
    Alzforum conference blog mentions EPAD
    2020-11-30
  • EPAD v1500 dataset
    New webpage dedicated to EPAD data and samples on the EPAD website
    2020-11-18
  • ADDI launches new Workbench to foster greater global research innovation and accelerate breakthroughs in Alzheimer’s disease and related dementias
    2020-11-17
  • New paper investigating the prediction of Alzheimer’s disease biomarker status
    2020-11-12
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@IMI_EPAD

We would like to thank all our followers! A massive thanks also goes to our research participants & members for all their support! Looking back on the years of the @IMI_EPAD project, here's key pictures took at major events. Have a safe & Happy New Year! youtu.be/FeYsOBOhCeo

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8:55 am · 2021-01-18
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EPAD
@IMI_EPAD

The videos from #30AEC are online! Check out the @IMI_EPAD presentations on #data sharing by @rodrigobarnes (@aridhia) & Colin Veal (@uniofleicester). Thanks @IMI2_NEURONET and @AlzheimerEurope for giving us the opportunity to present our work. imi-neuronet.org/2020-virtual… twitter.com/IMI2_NEURONET/…

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8:43 am · 2021-01-15
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EPAD
@IMI_EPAD

Authors investigated #data from nine studies, including @IMI_EPAD, comprising a total of 60,004 assessed participants. If you want to explore the #Alzheimer's disease data landscape, visit adata.scai.fraunhofer.de @BirkenbihlC @ApitiusHofmann @ddomingof @Simon_Lovestone @TVB_cloud

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7:56 am · 2021-01-11
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EPAD
@IMI_EPAD

Numerous studies have collected #Alzheimer's disease cohort #data sets. @BirkenbihlC and colleagues have evaluated the Alzheimer's disease data landscape from a patient‐level data‐centric perspective. @IMI_EPAD @IMI_EMIF @NACCALZ alz-journals.onlinelibrary.wi…

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7:48 am · 2021-01-11
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EPAD
@IMI_EPAD

The final @IMI_EPAD dataset is now available to the entire research community | News | @CORDIS_EU | European Commission europa.eu/!dj89jY

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12:55 pm · 2021-01-08
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This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD grant agreement nº 115736

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