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European Prevention of Alzheimer's Dementia Consortium
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Data

Data and samples have been collected from participants across a wide-range of outcomes at each annual visit, refer to the content below.  The 6-month visit collected data on cognition only.

You can download the EPAD protocol here.

For more information about the EPAD LCS protocol, refer to the following paper:

European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study (EPAD LCS): study protocol.

Alina Solomon et al. BMJ Open 2019 Feb 19;8(12):e021017.

DOI: 10.1136/bmjopen-2017-021017

 

Primary Outcomes

Cognitive Outcomes – RBANS Total Scale Index Score
  • Verbal Episodic Memory: List Learning & Story Memory
  • Visual Episodic Memory: Figure recall
  • Visuospatial/Constructional: Figure Copy & Line Orientation
  • Language: Picture Naming
  • Attention/Executive Functioning: Semantic Fluency, Digit Span, Coding

Secondary Outcomes

Cognitive Outcomes
  • Working Memory: Dot Counting (NIH EXAMINER)
  • Choice Reaction Time and Set Shifting: Flanker (NIH EXAMINER)
  • Paired Associate Learning: Favourites (University of California, San Francisco)
CSF Biomarker Outcomes
  • Aβ, t-tau, p-tau
Neuroimaging Outcomes (MRI)
  • Hippocampal & whole brain volume

Exploratory Outcomes

Cognitive Outcomes
  • Allocentric Space: Four Mountains Task (University College London/University of York)
  • Navigation in Egocentric Space: Virtual Reality Supermarket Trolley (University College London)
Other Clinical Outcomes
  • Everyday functioning: Amsterdam Instrumental Activities of Daily Living Questionnaire
Neuroimaging Outcomes
  • Multi-region structural and functional MRI analysis
  • Functional regional and network measures
CSF Biomarker Outcomes
  • TREM-2, neurofilament light, and neurogranin

Other Measures

  • Sociodemographic and lifestyle factors, family history of AD/dementia in first degree relatives, medical history, comorbidity, medication use, BMI, waist-hip ratio, blood pressure.
  • Clinical Dementia Rating Scale (CDR)
  • Mini Mental State Examination (MMSE)
  • Geriatric Depression Scale (GDS), State-Trait Anxiety Inventory (STAI), Pittsburgh Sleep Quality Index (PSQI).
  • Vascular burden (WML, infarcts, lacunes, microbleeds, superficial siderosis)
  • Dementia diagnosed by the participant’s physician
  • Physical examination
  • APOE genotype
  • Polygenic Risk Scores
  • Collection of CSF and blood, urine & saliva samples for future biomarker assessments (emerging AD biomarkers): beta-amyloid, t-tau, p-tau, (neurofilament light, TREM 2, and neurogranin).

 

 

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Latest News
  • Closing EPAD article published in the Alzheimer Europe magazine
    2021-02-24
  • Alzheimer Europe launches a report on data sharing in dementia research
    2021-02-23
  • Local actions to keep the EPAD Longitudinal Cohort data collection going
    2021-02-17
  • Neuronet releases its Knowledge Base dashboard
    2021-02-01
  • The final EPAD dataset is now available to the entire research community
    2020-11-30
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@AD_PREVENT @alzassociation @alzheimerssoc Congratulations to all the team 👏

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7:03 am · 2021-03-01
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.@AlzheimerEurope has published a new edition of its “Dementia in Europe” magazine. It includes a closing article on @IMI_EPAD. Our co-leads @craig_ritchie68 and Serge Van der Geyten, reflect on the achievements of the project. Download the PDF here: bit.ly/DementiaInEuro… twitter.com/AlzheimerEurop…

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12:40 pm · 2021-02-24
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Last week, we held the first local @IMI_EPAD community meeting among the Scottish research sites, collaborators, academics & scientists who have been involved in our Longitudinal Cohort Study and now continue to contribute to the study locally More info⤵️ ep-ad.org/2021/02/17/loc… pic.twitter.com/MTKmanCURk

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6:51 am · 2021-02-24
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Check out the new @AlzheimerEurope report on #DataSharing in #dementia #research, which reviews recent changes in EU research policy and sets out recommendations to improve data sharing. It includes case studies from ADNI, @IMI_EPAD and @IMI_EMIF. ⬇️ Bit.ly/DataSharing_AE twitter.com/AlzheimerEurop…

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2:39 pm · 2021-02-23
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Scottish @IMI_EPAD members have been invited to join the first #EPADcommunity meeting. Today, we're discussing about publications, #data access, communications, participant panel, #network & #collaborations. Nice to see some #epadistas sharing their insights 👨‍⚕️👩‍🔬👩‍💻 pic.twitter.com/O1hLAVxk0Q

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2:23 pm · 2021-02-17
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This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD grant agreement nº 115736

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