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European Prevention of Alzheimer's Dementia Consortium
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The EPAD Proof of Concept Platform

The EPAD platform was developed to speed up the development of effective, safe medicines which slow or prevent the development of Alzheimer’s dementia. Although, we were unable to initiate a Proof of Concept Trial, we want to share the EPAD experience on the development of platform trials.

Our trial-ready proof-of-concept (PoC) platform was developed to run Phase II clinical trials with research participants with preclinical and prodromal Alzheimer’s disease, with biomarker evidence of Alzheimer’s disease pathology using a consistent set of outcomes. EPAD was unique in its ability to recruit from the EPAD readiness cohort, guaranteeing recruitment and ensuring a low (10%) screen failure rate.

The platform was open for expressions of interest from pharmaceutical and biotechnology organisations, academic researchers, and funders which had suitable interventions ready for testing.

How Does EPAD Worked?

The platform was designed to efficiently deliver early, accurate results. EPAD studied new drugs in a well-designed Phase II PoC trial with clinical endpoints, utilising the power of adaptive design and Bayesian statistics.

To support this process, we developed three core strategies that offered support and guidance in selecting the optimal trial populations for aspecific compound.

1 The Register

EPAD has created the first single, pan-European register of over half a million people across the risk spectrum for dementia.

2 The Cohort

From this register, participants were invited to join an EPAD cohort, the Longitudinal Cohort Study. This group underwent standardised tests and follow-up over several years.

3 The Trial

EPAD aimed to select suitable participants to take part in streamlined PoC trials of drugs designed to prevent Alzheimer’s dementia.

 

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Latest News
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    2021-04-06
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If you're attending #BNA2021, check out the pre-registration poster from @GregorySarah introducing the SPeAk study. Participants of this new study must have previously enrolled in the @IMI_EPAD LCS or CHARIOT Pro study at @CenDemPrevent. #biomarker #Alzheimer’s disease #dementia twitter.com/CenDemPrevent/…

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10:18 am · 2021-04-14
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Check out the last @IMI_EPAD publication on the application of the #ATN classification scheme in the first 1500 participants consented in the EPAD Longitudinal Cohort Study. ep-ad.org/2021/04/06/new… @silvia_ingala @IMI_JU @EFPIA @EU_H2020 pic.twitter.com/3HhgMcBDN0

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8:15 am · 2021-04-13
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The @IMI_EPAD Bioresource consists of over 100,000 samples consisting of blood, CSF, saliva and urine that have been collected annually from research participants throughout their participation in the Longitudinal Cohort Study. #OpenAccess ep-ad.org/2021/03/10/epa… twitter.com/IMI_EPAD/statu… pic.twitter.com/dRjuI1opFi

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7:16 am · 2021-04-12
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The ATN classification has been added for public use to the analytical database of the @IMI_EPAD Longitudinal Cohort Study, hosted by @aridhia . ⬇️ ep-ad.org/2021/04/06/new… twitter.com/IMI_EPAD/statu…

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5:56 am · 2021-04-07
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In this article, the #ATN classification was operationalized in the first 1500 participants consented in the @IMI_EPAD cohort, a deeply phenotyped cohort of individuals who do not have #dementia. ep-ad.org/2021/04/06/new…

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7:08 am · 2021-04-06
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This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD grant agreement nº 115736

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