loading...

File Properties

  • Contact
  • EPAD Academy
Top Bar Menu
TwitterFacebookYouTube
Search...
EPADEPAD
EPAD
European Prevention of Alzheimer's Dementia Consortium
  • Home
  • About
    • Welcome to EPAD
    • Project Objectives
    • Project Structure
    • EPAD Partners
    • Coordination & Management
    • EPAD Q&A
  • Our research
    • Participation in EPAD
      • Participation in EPAD Cohort
      • EPAD Study Visits
      • Trial Locations
      • Participation FAQs
    • The Participant’s Experience
      • The Research Participant Panel
      • EPAD Stories
    • The EPAD platform
      • The EPAD Platform
      • EPAD Benefits
      • Clinical Candidate Selection
      • EPAD FAQs
      • Research Resources
  • Open Access Data
    • Overview
    • Access
    • Data
    • MRI Images
  • Sample Access
  • News & Publications
    • Latest News
    • Newsletters
    • Publications
    • Videos
Menu back  

EPAD Project Structure

EPAD was coordinated by Serge Van der Geyten and Craig Ritchie.
The success of this Project was underpinned by the coordinated activity of the different Work Packages (WPs). Although the 8 WPs are described separately below, to achieve the Project’s goals, close collaboration and cross-cutting actions of the different WPs were crucial.

Work Package 1: Scientific Challenges

Description

Integrates the scientific input to the project and addresses the central questions in AD disease modification that will drive the design of the EPAD adaptive clinical trial: who the subjects are, how should they be assessed, and with what should they be treated?

Objectives
  • To define a spectrum of individuals at risk of developing dementia due to AD.
  • To define the evaluation criteria for inclusion of participants into the EPAD Register, EPAD Cohort and EPAD Trial, and the relevant biomarkers, clinical assessments and endpoints.
  • To assess and select potential trial mechanisms and compounds, through a Clinical Candidate Selection Committee.
  • To establish and coordinate four Scientific Advisory Groups (SAGs) referring to key scientific areas that gather the needed, high-level scientific knowledge to support decisions made in WP1.
Leads

José Luis Molinuevo (BBRC)
Gary Romano (Janssen)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating
WP1 Deliverable 1.1 - Evaluation of pre-clinical and prodromal diagnostic criteria, risk spectrum and inclusion criteria for Register and Cohort
  • » epad_d1.1_evaluationcriteria.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
2236 downloads 1.0 11-02-2015
WP1 Deliverable 1.2 - Description of Compound Selection criteria and decision tree for Proof of Concept trial
  • » epad_d1.2_compoundcriteriadecisiontree.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
2405 downloads 1.0 22-12-2015
WP1 Deliverable 1.3 - Interim Report on Biomarkers, Clinical Assessments, and Outcome Measures
  • » epad_d1.3_interimreportbiomarkclinout.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1685 downloads 1.0 02-02-2016
WP1 Deliverable 1.4 - Scientific report on compound inclusion for trial
  • » epad_d1.4_compoundselection.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1558 downloads 1.0 12-07-2016
WP1 Deliverable 1.5- Interim Report on the Scientific Recommendations and Key Outcomes
  • » 115736_epad_d1.5_reportrecomendationsoutcomeslcs.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1551 downloads 1.0 10-08-2017
WP1 Deliverable 1.6- Interim report on evaluation of biomarker and clinical assessments and outcomes from existing and acquired data
  • » 115736_EPAD_D1.6_Interim report on evaluation of biomarker and clinical assessments and outcomes from existing and acquired data_Final.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1402 downloads 1.0 30-01-2019
WP1 Deliverable 1.7- Final assessment for sustained EPAD Cohort and Trials
  • » WP1 Deliverable 1.7- Final assessment for sustained EPAD Cohort and Trials.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
755 downloads 1.0 06-07-2020
WP1 Deliverable 1.8 - Establishment of the EPAD LCS Research Access Committees
  • » 115736_EPAD_D1.8_Establishment of the EPAD LCS Research Access Committees.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1036 downloads 1.0 24-01-2020
WP1 Deliverable 1.9 - EPAD Research Access Process (ERAP) Operational Report
  • » 115736_EPAD_D1.9_ERAP_Operations_Report_Final_V2.0.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
827 downloads 1.0 04-09-2020

Work Package 2: Statistical/Methodology Engine Room

Description

The anchor for knowledge management, this WP receives all data from the EPAD register, cohort and trial for analysis to continually inform disease modelling and adaptive trial design decisions. It gathers the tools and resources that will be used for disease modelling, assessing and preparing them for exploitation and setting up procedures to design the adaptive trial.

Objectives
  • To develop and optimize disease modelling and simulation software supporting risk modelling and adaptive clinical trial design and updates.
  • To develop disease and risk modelling capacity based on existing and acquired data via EPAD Cohort and Trial activities informing scientific assessment in WP1 and trial design updates.
  • To build the interventional adaptive trial design and needed methodology, providing updates to the design, analysis of new interventions and of existing compounds.
Leads

Scott Berry (Berry Consultants)
Shobha Dhadda (Eisai)
Adrian Mander (MRC)
Philip Hougaard (Lundbeck)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating
WP2 Deliverable 2.1 - Report on resources to be used for Disease modelling
  • » epad_d2.1_modellingresources_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1706 downloads 1.0 14-09-2015
WP2 Deliverable 2.10- Final report on integrative data mining, including software updates
  • » WP2 Deliverable 2.10- Final report integrative data mining incl sofware updates.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
703 downloads 1.0 13-07-2020
WP2 Deliverable 2.2 - Initial skeleton design
  • » epad_d2.2_skeletondesign_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1512 downloads 1.0 18-11-2015
WP2 Deliverable 2.3 - Initial version of optimized model fitting software
  • » epad_d2.3_modelfittingsoftware_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1644 downloads 1.0 21-06-2016
WP2 Deliverable 2.4 - Draft Design Report complete for finalized design from the simulation process
  • » epad_d2.4_simulationsreport_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1580 downloads 1.0 10-10-2016
WP2 Deliverable 2.5- Operational Process Document
  • » WP2 Deliverable 2.5- Operational Process Document.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1306 downloads 1.0 31-10-2018
WP2 Deliverable 2.6- Disease Risk Modelling
  • » wp2deliverable2.6-diseaseriskmodelling.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1474 downloads 1.0 13-07-2017
WP2 Deliverable 2.7- Update to the design based on disease-risk model and scientific reassessment
  • » 115736_EPAD_115736_EPAD_D2.7_Update Design based on disease risk-model and scientific re-assessment.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
694 downloads 1.0 01-10-2020
WP2 Deliverable 2.8- Disease risk Modelling Report V2
  • » wp2deliverable2.8-diseaseriskmodellingv2.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1355 downloads 1.0 13-02-2018
WP2 Deliverable D2.11 - Master Statistical Analysis Plan for the EPAD Platform Proof-of-Concept Trial
  • » 115736_EPAD_D2.11_POC Statistical Analysis Plan_V2.0.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
990 downloads 1.1 EPAD Administrator3 27-01-2021

Work Package 3: Parent Cohorts and EPAD Register

Description

Creates and maintains the EPAD register in the form of full “fingerprinting” of parent cohorts.

Objectives
  • To provide the methods and tools to identify, characterise and select Parent Cohorts suitable for contributing to the EPAD Register.
  • To provide the methods and tools to identify and select suitable participants from Parent Cohorts to build the EPAD Register, enabling the appropriate data discovery/sharing capacity and underpinning policies.
  • To define operational processes and arrangements for maintenance and replenishment of the EPAD Register.
Leads

Pieter-Jelle Visser (VUmc)
Gerald Luscan (Pfizer)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating

No files found in this folder.

Work Package 4: EPAD Cohort and EPAD Trials

Description

WP4 focuses on the selection and certification of the EPAD trial delivery centres, and the EPAD Cohort protocol early in the project, as well as the design and execution of the Proof-of-Concept (PoC) study. This team also oversees the execution of the protocols for the EPAD cohort and trials and work with National/Regional Leads and Clinical Research Organisations (CROs) on qualification, establishment and training of the EPAD trial delivery centres.

Objectives
  • To establish certified EPAD TDCs across Europe capable of recruiting the needed number of subjects for the EPAD Cohort and Trial.
  • To establish the EPAD Cohort and related data flows, databasing infrastructure, quality control/assurance and monitoring procedures.
  • To sign off the EPAD Cohort Protocol and implement it.
  • To sign off the EPAD Trial Master Protocol and Appendices implement them.
  • To establish a Principal Investigators Network supporting EPAD Cohort and Trial activities.
Leads

Lisa Ford (Janssen)
Craig Ritchie (University of Edinburgh)
Catherine Debove (Boehringer)
Miia Kivipelto (Karolinska Institutet)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating

No files found in this folder.

Work Package 5: Project Management

Description

Provides professional project management to EPAD.

Objectives
  • To set-up a project management structure that ensures efficient operational and timely execution of the Project.
  • To guarantee project is executed according to the work plan and scientific activities are managed efficiently.
  • To manage resources, procedures and tools for ensuring that all expected results are delivered on time, with an adequate quality level and within cost, including risk management and quality control procedures on deliverables.
  • To ensure effective communication and work dynamics between Participants to help drive the whole Consortium as a team towards successful completion of the Project.
Leads

Carlos Diaz (Synapse)
Serge Van der Geyten (Janssen)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating
WP5 Deliverable 5.1 - Restricted Website and Tools for Internal Collaboration and Communication
  • » epad_d5.1_internalcollaborationplatform.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
2067 downloads 1.0 23-02-2015
WP5 Deliverable 5.2 - EPAD Project Handbook
  • » epad_d5.2_projecthandbook_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1449 downloads 1.0 19-06-2015
WP5 Deliverable 5.5 - Project Assessment
  • » WP5 Deliverable 5.5-Project Assessment.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1039 downloads 1.0 23-01-2018

Work Package 6: Dissemination

Description

Leads and coordinates external dissemination activities, outreach to specific external stakeholders and a public health campaign with special emphasis on the importance of AD prevention. The WP6 team also assesses the impact and effectiveness of dissemination activities.

Objectives
  • To develop a dissemination and communication plan including objectives, target audiences, tools and activities.
  • To develop and update the needed tools to implement the planned dissemination activities.
  • To carry out a variety of dissemination activities aiming at maximising exposure of the project while optimising the project’s perception among the different target audiences.
Leads

Sean Knox (Biogen)
Jean Georges (Alzheimer Europe)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating
WP6 Deliverable 6.1 - Initial Communication Plan, including project branding and policies
  • » epad_d6.1_commsplan_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1589 downloads 1.0 29-07-2015
WP6 Deliverable 6.2 - Initial Report on communication tools and material
  • » epad_d6.2_report_comms_tools_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1362 downloads 1.0 29-02-2016
WP6 Deliverable 6.3- Interim report on dissemination activities
  • » wp6deliverable6.3-interimreportondisseminationactivities.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1348 downloads 1.0 17-07-2017
WP6 Deliverable 6.4- Updated communications plan, tools and materials
  • » WP6 Deliverable 6.4- Updated communications plan tools and materials.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1063 downloads 1.0 29-03-2018
WP6 Deliverable 6.5- Impact and Evaluation Report
  • » WP6 Deliverable 6.5- Impact and evaluation report.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
614 downloads 1.0 03-11-2020

Work Package 7: Business Model and Sustainability

Description

Analyses markets, stakeholders, incentives and schemes for pre-competitive intellectual property handling in order to develop a viable business plan for sustainability of the EPAD ‘machine’ and network of centres beyond the project’s timeframe.

Objectives
  • To study existing and emerging public-private partnership collaborative models that can be useful for the EPAD sustainability.
  • To analyse the stakeholder types intervening in EPAD, their interests and incentives towards sustainability.
  • To analyse and develop procedures for a pre-competitive space that caters to a variety of companies and therapies.
  • To analyse and develop procedures that enable the EPAD infrastructure of TDCs to be sustained over time.
  • To develop a solid business plan that enables transition of EPAD to the post-project phase for long term sustainability.
Leads

Serge Van der Geyten (Janssen)
José Luis Molinuevo (BBRC)
Saira Ramasastry (Synapse)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating
WP7 Deliverable 7.1 - Establishment of a Business Leadership Committee
  • » epad_d7.1_blc.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1933 downloads 1.0 16-04-2015
WP7 Deliverable 7.2 - Analysis of existing public-private partnerships
  • » epad_d7.2_publicprivatepartnershipsanalysis_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1498 downloads 1.0 21-12-2015
WP7 Deliverable 7.3 - Stakeholder Analysis
  • » epad_d7.3_stakeholderanalysis_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1426 downloads 1.0 27-06-2016
WP7 Deliverable 7.4- Configuration of a Pre-Competitive Space, IPR Handling and Business Flows
  • » wp7deliverable7.4-configurationofapre-competitivespaceiprhandlingandbusinessflows.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1308 downloads 1.0 04-12-2017
WP7 Deliverable 7.5 - Workflows and Procedures of the EPAD Network Centers
  • » epad_d7.5_workflows_procedures_network_centers_abstract.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1313 downloads 1.0 EPAD Administrator3 15-05-2017
WP7 Deliverable 7.6- Business Plan v1
  • » WP7 Deliverable 7.6- Business Plan v1.docx
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
1110 downloads 1.0 19-12-2018
WP7 Deliverable 7.7-Business Plan v2
  • » WP7 Deliverable 7.7- Business Plan v2.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
632 downloads 1.0 02-07-2020
WP7 Deliverable 7.8 - Report on the EPAD Academy, including ERAP
  • » WP 7 Deliverable 7.8-Report on the EPAD Academy including ERAP.pdf
  • File Options
  • Download
  • Description
  • Preview
  • Other Versions
  • Goto Post
750 downloads 1.0 09-01-2020

Work Package 8: Ethical, Legal and Social Implications

Description

Studies the critical ethical, legal and social issues (ELSI) pertaining to the project and provides guidance on informed consent, privacy, disclosure of findings and data sharing.

Objectives
  • Define an EPAD ethics and information governance framework for recruiting from existing cohort studies.
  • Develop a robust strategy for involving research subjects in the development of ethics procedures and research protocols.
  • Investigate the ethical, legal and social implications of disclosure of biomarker results and the associated risk of AD dementia.
  • Evaluate and compare the feasibility and impact of large-scale biomarker-testing within national health care systems.
  • Investigate and advise on the recruitment of subjects for Phase 2 trials from existing cohort studies.
Leads

Shirlene Badger (University of Cambridge)
Edo Richard (RUMC)
Carol Brayne (University of Cambridge)

Deliverables
Name Downloads Version Owner Last Modified Rating
Name Downloads Version Owner Last Modified Rating

No files found in this folder.

Share this page
FacebookTwitterLinkedInGoogle+
Latest News
  • Data from AMYPAD PNHS is now available on the AD Workbench
    2023-07-04
  • New paper showing Eigenvector centrality (EC) alterations in the pre-dementia stages of Alzheimer’s disease
    2023-03-28
  • Analysis of multiple steroids in saliva in the EPAD study
    2023-03-02
  • Hormone Replacement Therapy could ward off Alzheimer’s among at-risk women
    2023-01-16
  • Associations between Mediterranean diet and cognition in the pan-European EPAD LCS
    2022-12-09
View the EPAD Brochure
thumbnail of EPAD brochure
Speak to the EPAD team
thumbnail of speech bubbles
Twitter
Workstream Progress
Workstream 120%
Workstream 232%
Workstream 310%
Workstream 446%
Contact us

Submitclear

Recent Posts
  • Data from AMYPAD PNHS is now available on the AD Workbench
  • New paper showing Eigenvector centrality (EC) alterations in the pre-dementia stages of Alzheimer’s disease
  • Analysis of multiple steroids in saliva in the EPAD study
  • Hormone Replacement Therapy could ward off Alzheimer’s among at-risk women
  • Associations between Mediterranean diet and cognition in the pan-European EPAD LCS
Recent Comments
  • The EPAD genomic data is now available on the Alzheimer’s Disease Workbench on The EPAD genomic data is now available on the Alzheimer’s Disease Workbench
  • ADDI celebrates one year of achievements – Neuronet on ADDI celebrates one year of achievements
  • EPAD dataset is now available on the Alzheimer’s Disease Workbench on The final EPAD dataset is now available on the Alzheimer’s Disease Workbench
  • The final EPAD dataset is now available to the entire research community on The final EPAD dataset is now available to the entire research community
  • The ERC has awarded an ERC grant to identify age-related human blood factors as a therapeutic target for Alzheimer’s disease – Neuronet on New ERC starting grant to identify age-related human blood factors as a therapeutic target for Alzheimer’s disease
Archives
  • July 2023
  • March 2023
  • January 2023
  • December 2022
  • November 2022
  • October 2022
  • September 2022
  • August 2022
  • July 2022
  • June 2022
  • May 2022
  • April 2022
  • March 2022
  • January 2022
  • November 2021
  • October 2021
  • September 2021
  • August 2021
  • July 2021
  • June 2021
  • May 2021
  • April 2021
  • March 2021
  • February 2021
  • November 2020
  • October 2020
  • September 2020
  • July 2020
  • June 2020
  • April 2020
  • March 2020
  • February 2020
  • January 2020
  • December 2019
  • November 2019
  • October 2019
  • September 2019
  • August 2019
  • July 2019
  • June 2019
  • May 2019
  • April 2019
  • March 2019
  • February 2019
  • January 2019
  • December 2018
  • November 2018
  • October 2018
  • September 2018
  • August 2018
  • July 2018
  • June 2018
  • May 2018
  • April 2018
  • March 2018
  • February 2018
  • January 2018
  • December 2017
  • November 2017
  • October 2017
  • September 2017
  • July 2017
  • June 2017
  • May 2017
  • April 2017
  • March 2017
  • February 2017
  • January 2017
  • December 2016
  • November 2016
  • October 2016
  • September 2016
  • August 2016
  • July 2016
  • June 2016
  • May 2016
  • April 2016
  • March 2016
  • February 2016
  • January 2016
  • December 2015
  • November 2015
  • October 2015
  • September 2015
  • August 2015
  • June 2015
  • May 2015
  • April 2015
Categories
  • EPAD Academy
  • News
Meta
  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org
Copyright © 2015-2021 EPAD | Created by CMAST and Aridhia
  • Acronyms
  • Legal Notice
  • Privacy Policy
Bottom Menu

efpia-logo EU imi logo

This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD grant agreement nº 115736

This website uses cookies to improve your experience. Accept Read More
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Non-necessary
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
SAVE & ACCEPT

Insert/edit link

Enter the destination URL

Or link to existing content

    No search term specified. Showing recent items. Search or use up and down arrow keys to select an item.